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Lariam
Lariam
Generic Name: Mefloquine (ME-floe-kwin)
Brand Name: Lariam
Lariam is used for:
Treating or preventing malaria.
Lariam is an antimalarial agent. How it works to kill sensitive malaria parasites is not known.
Do NOT use Lariam if:
- you are allergic to any of the ingredients contained in Lariam or similar medicines (eg, quinine, quinidine)
- you have a mental illness (eg, anxiety disorder, schizophrenia, psychosis) or you have a history of depression or seizures
- you are taking halofantrine
Contact your health care provider as soon as possible if any of the above applies to you.
Consider before using Lariam
Medical Conditions
There are medical conditions that can influence usage of Lariam . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any medicine (either prescription or nonprescription), herbal preparation, or dietary supplement
- if you have allergies to medicines (especially quinine or quinidine), foods, or other substances
- if you have a history of mental disorders, heart disease, epilepsy, diabetes, or liver problems
Drugs Interaction
There are medicines that may interact with Lariam . Inform your health care provider if you are taking any other medicines, in particular any from the list below:
- Beta-blockers (eg, atenolol), dofetilide, halofantrine, or ziprasidone because heart problems, including irregular heartbeat, may occur
- Ethanol because severe psychiatric disturbances may result
- Oral live vaccines because the effectiveness of the vaccine may be decreased. Oral live vaccines should be completed at least 3 days before the first dose of Lariam .
This is not a full list of all interactions that may occur. Clarify with your health care provider whether Lariam may interact with other medicines you take. Also, consult your health care provider in advance if you are going to start, stop, or change the dose of any medicine.
Lariam Usage Guidelines
You should use Lariam as recommended by your doctor. Read the medicine's label for precise dosing instructions.
- Lariam comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Lariam refilled.
- Lariam should not be taken on an empty stomach. It should be taken with food and at least a full glass of water (8 oz/240 mL).
- If the tablets cannot be swallowed whole, they may be crushed and suspended in a small amount of water, sugar water, milk, or other beverage. Be sure to drink all the liquid so that you receive the entire dose.
- Patients taking Lariam to prevent malaria should begin 1 week prior to traveling and continue for 4 weeks after leaving the area where malaria can be contracted. If you are unable to complete the course of treatment, contact your doctor.
- Weekly doses of Lariam should be taken regularly, on the same day of each week, preferably after the main meal.
- Continue using Lariam for the full course of treatment. Do not skip any doses.
- If you miss a dose of Lariam and you are taking it to prevent infection, take it as soon as you get it remembered. However, if it is almost time for the next dose, ignore the missed one and get back to your normal dosing schedule. Do not take 2 doses at the same time.
Clarify with your health care provider any issues you may have about usage of Lariam .
Important safety information on lariam
- Lariam may cause drowsiness, dizziness, lightheadedness, or a loss of balance. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Lariam . Using Lariam alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
- Carry an identification card at all times that says you taking Lariam .
- Malaria can be life-threatening. Lariam is helps to prevent or treat the infection.
- No medicine is completely effective against malaria. While you are in a hazardous area, use bed nets and insect repellents and wear protective clothing (long sleeves and long pants) to decrease your risk. If you are out in the bush, you may want to pre-wash your clothes with permethrin, a mosquito repellent that may be effective for weeks after use. Ask your doctor for other ways to protect yourself.
- Contact your health care provider at once if you develop a fever or flu-like symptoms (eg, chills, muscle pains, headache) after returning from an area where malaria exists.
- Lariam may cause early vomiting in children. If a significant amount of Lariam is lost due to vomiting, a second full dose of it should be given to patients who vomit less than 30 minutes after receiving it. If vomiting occurs 30 minutes to 1 hour after a dose, an additional half-dose should be given. Monitor the patient closely if vomiting occurs again.
- Stop using Lariam and contact your health care provider if anxiety, depression, restlessness, or confusion occur. Lariam should not be used for retreatment if a full course of Lariam does not lead to improvement within 48 to 72 hours. Your doctor may need to prescribe an alternative medicine. If you do not have access to a health care provider or to another medicine and you have to stop taking this one, leave the malaria area. Leaving the area may not protect you from contracting malaria and you may still need to take another medicine to prevent the disease.
- Use effective contraception (birth control) (eg, diaphragms) while taking Lariam and for 3 months after you have taken it.
- If you are taking other medicines, it may be necessary to start treatment with Lariam 2 to 3 weeks before traveling in order to make sure the other medicines and Lariam are well tolerated.
- Certain vaccines may not work if taken while using Lariam . Vaccinations with live bacteria should be completed at least 3 days before taking the first dose of Lariam .
- Diabetes patients - Lariam may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
- Additional monitoring of your dose or condition may be needed if you are taking quinidine, chloroquine, medicine for seizures (eg, carbamazepine, phenytoin, valproic acid), or blood thinners (eg, warfarin).
- LAB TESTS, including liver function tests and eye exams, may be performed to monitor your progress or check for side effects if you are taking Lariam for a long period of time. Be sure to keep all doctor and lab appointments.
- Use Lariam with caution in the ELDERLY because they may be more sensitive to its effects, especially heart problems.
- Lariam is not recommended for use in CHILDREN younger than 6 months of age. Safety and effectiveness in this age group have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Avoid becoming pregnant while using Lariam . If you become pregnant, discuss with your doctor the benefits and risks of using Lariam during pregnancy. Lariam is excreted in breast milk. Do not breast-feed while taking Lariam .
Side effects may be caused by Lariam
All medicines may cause side effects, but many people have no, or minor, side effects. Consult your doctor if any of the most COMMON side effects from the list below persist or start bothering you:
Seek medical care immediately if any of the following SEVERE side effects occur:Diarrhea; dizziness; drowsiness; fainting; fever; hair loss; headache; insomnia; lightheadedness; loss of appetite; loss of balance; muscle aches; nausea; ringing in the ears; stomach pain or upset; strange dreams; tiredness; vomiting.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; fast, slow, or irregular heartbeat; flu-like symptoms (chills, fever, muscle pain, headache); loss of coordination; muscle pain; numbness and tingling of hands or feet; paranoia; seizures; suicidal thoughts or behaviors; unexplained anxiety, mood changes, depression, hallucinations, restlessness, or confusion; vision changes.
It sholud be noted, that this is not a full list of possible side effects. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include diarrhea; vomiting.
Lariam storage instructions:
Store Lariam at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep out of the reach of children and away from pets.
General information:
- If you have any questions on Lariam , please consult your doctor, pharmacist, or health care provider.
- Lariam is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or even become worse, inform your doctor.
This article is a summary only, and it does not provide all the information about Lariam . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Consumer Information (MedFacts)
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